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Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

Miosge, Lisa A.; Sontani, Yovina; Chuah, Aaron; Horikawa, Keisuke; Russell, Tiffany A; Mei, Yan; Wagle, Mayura V; Howard, Debbie; Enders, Anselm; Tscharke, David C; Goodnow, Christopher C; Parish, Ian A

Description

T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphocytes to form effector cells. Here we identify a critical role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritize mutations in genes of unknown function with potential effects on the immune system, followed by breeding to homozygosity and testing for immune system phenotypes. Effector CD8+ and CD4+ T-cell...[Show more]

CollectionsANU Research Publications
Date published: 2017-06-27
Type: Journal article
URI: http://hdl.handle.net/1885/155584
Source: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.1705795114
Access Rights: Open Access

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