Skip navigation
Skip navigation
Open Research is currently undergoing maintenance with the search being reindexed. The number of items available to be searched will return over time on Wednesday, 12 May 2021.

Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

Miosge, Lisa A.; Sontani, Yovina; Chuah, Aaron; Horikawa, Keisuke; Russell, Tiffany A; Mei, Yan; Wagle, Mayura V; Howard, Debbie; Enders, Anselm; Tscharke, David C; Goodnow, Christopher C; Parish, Ian A


T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphocytes to form effector cells. Here we identify a critical role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritize mutations in genes of unknown function with potential effects on the immune system, followed by breeding to homozygosity and testing for immune system phenotypes. Effector CD8+ and CD4+ T-cell...[Show more]

CollectionsANU Research Publications
Date published: 2017-06-27
Type: Journal article
Source: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.1705795114
Access Rights: Open Access


File Description SizeFormat Image
Proc Natl Acad Sci USA 2017 Miosge.pdfJournal article1.14 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator