Effect of Aspirin on All-Cause Mortality in the Healthy Elderly
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McNeil, John J.; Nelson, Mark R.; Woods, Robyn L.; Lockery, Jessica E.; Wolfe, Rory; Reid, Christopher M.; Kirpach, Brenda; Shah, Raj C.; Ives, Diane G.; Storey, Elsdon; Ryan, Joanne; Tonkin, Andrew M.; Newman, Anne B.; Williamson, Jeff D.; Margolis, Karen L.; Ernst, Michael E.; Abhayaratna, Walter; Stocks, Nigel; Fitzgerald, Sharyn M.; Orchard, Suzanne G.; Trevaks, Ruth E.; Beilin, Lawrence J.; Donnan, Geoffrey A.; Gibbs, Peter; Johnston, Colin I.; Radziszewska, Barbara; Grimm, Richard; Murray, Anne M.
Description
BACKGROUND In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo. METHODS From 2010 through 2014, we enrolled community-dwelling persons in Australia and the...[Show more]
dc.contributor.author | McNeil, John J. | |
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dc.contributor.author | Nelson, Mark R. | |
dc.contributor.author | Woods, Robyn L. | |
dc.contributor.author | Lockery, Jessica E. | |
dc.contributor.author | Wolfe, Rory | |
dc.contributor.author | Reid, Christopher M. | |
dc.contributor.author | Kirpach, Brenda | |
dc.contributor.author | Shah, Raj C. | |
dc.contributor.author | Ives, Diane G. | |
dc.contributor.author | Storey, Elsdon | |
dc.contributor.author | Ryan, Joanne | |
dc.contributor.author | Tonkin, Andrew M. | |
dc.contributor.author | Newman, Anne B. | |
dc.contributor.author | Williamson, Jeff D. | |
dc.contributor.author | Margolis, Karen L. | |
dc.contributor.author | Ernst, Michael E. | |
dc.contributor.author | Abhayaratna, Walter | |
dc.contributor.author | Stocks, Nigel | |
dc.contributor.author | Fitzgerald, Sharyn M. | |
dc.contributor.author | Orchard, Suzanne G. | |
dc.contributor.author | Trevaks, Ruth E. | |
dc.contributor.author | Beilin, Lawrence J. | |
dc.contributor.author | Donnan, Geoffrey A. | |
dc.contributor.author | Gibbs, Peter | |
dc.contributor.author | Johnston, Colin I. | |
dc.contributor.author | Radziszewska, Barbara | |
dc.contributor.author | Grimm, Richard | |
dc.contributor.author | Murray, Anne M. | |
dc.date.accessioned | 2018-12-12T00:47:42Z | |
dc.identifier.issn | 0028-4793 | |
dc.identifier.uri | http://hdl.handle.net/1885/154655 | |
dc.description.abstract | BACKGROUND In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo. METHODS From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanics in the United States) and did not have cardiovascular disease, dementia, or disability. Participants were randomly assigned to receive 100 mg of enteric-coated aspirin or placebo. Deaths were classified according to the underlying cause by adjudicators who were unaware of trial-group assignments. Hazard ratios were calculated to compare mortality between the aspirin group and the placebo group, and post hoc exploratory analyses of specific causes of death were performed. RESULTS Of the 19,114 persons who were enrolled, 9525 were assigned to receive aspirin and 9589 to receive placebo. A total of 1052 deaths occurred during a median of 4.7 years of follow-up. The risk of death from any cause was 12.7 events per 1000 person-years in the aspirin group and 11.1 events per 1000 person-years in the placebo group (hazard ratio, 1.14; 95% confidence interval [CI], 1.01 to 1.29). Cancer was the major contributor to the higher mortality in the aspirin group, accounting for 1.6 excess deaths per 1000 person-years. Cancer-related death occurred in 3.1% of the participants in the aspirin group and in 2.3% of those in the placebo group (hazard ratio, 1.31; 95% CI, 1.10 to 1.56). CONCLUSIONS Higher all-cause mortality was observed among apparently healthy older adults who received daily aspirin than among those who received placebo and was attributed primarily to cancer-related death. In the context of previous studies, this result was unexpected and should be interpreted with caution. | |
dc.description.sponsorship | Supported by a grant (U01AG029824) from the National Institute on Aging and the National Cancer Institute at the National Institutes of Health, by grants (334047 and 1127060) from the National Health and Medical Research Council of Australia, and by Monash University and the Victorian Cancer Agency | |
dc.publisher | Massachusetts Medical Society | |
dc.source | The New England journal of medicine | |
dc.subject | administration, oral | |
dc.subject | aged | |
dc.subject | aged, 80 and over | |
dc.subject | aspirin | |
dc.subject | australia | |
dc.subject | cause of death | |
dc.subject | female | |
dc.subject | follow-up studies | |
dc.subject | hemorrhage | |
dc.subject | humans | |
dc.subject | independent living | |
dc.subject | male | |
dc.subject | neoplasms | |
dc.subject | platelet aggregation inhibitors | |
dc.subject | treatment failure | |
dc.subject | united states | |
dc.subject | mortality | |
dc.title | Effect of Aspirin on All-Cause Mortality in the Healthy Elderly | |
dc.type | Journal article | |
local.identifier.citationvolume | 379 | |
dcterms.dateAccepted | 2018-09-16 | |
dc.date.issued | 2018 | |
local.identifier.ariespublication | u4485658xPUB1356 | |
local.type.status | Published Version | |
local.contributor.affiliation | College of Medicine, Biology and the Environment (CMBE) | |
dc.relation | http://purl.org/au-research/grants/nhmrc/334047 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/1127060 | |
local.identifier.essn | 1533-4406 | |
local.bibliographicCitation.issue | 16 | |
local.bibliographicCitation.startpage | 1519-1528 | |
local.bibliographicCitation.lastpage | 1528 | |
local.identifier.doi | 10.1056/NEJMoa1803955 | |
dcterms.accessRights | Open Access | |
dc.provenance | "Publisher's version/PDF must be used on non-profit open access repository, including institutional repository" from SHERPA/RoMEO site | |
Collections | ANU Research Publications |
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