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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Wood, Angela M; Kaptoge, Stephen; Butterworth, Adam S; Willeit, Peter; Warnakula, Samantha; Bolton, Thomas; Paige, Ellie; Paul, Dirk S; Sweeting, Michael; Burgess, Stephen; Bell, Steven; van Schoor, Natasja; Boeing, Heiner; Overvad, Kim; Kauhanen, Jussi; Palmieri, Luigi; Wareham, Nick; Yeap, Bu B; Langenberg, Claudia; Forouhi, Nita; Rodriguez, Beatriz; Paige, Ellie; Wennberg, Maria; Després, Jean-Pierre; Cushman, Mary; Cooper, Jackie A; Rodriguez, Carlos J; Sakurai, Masaru; Dallongeville, Jean; Shaw, Jonathan E; Knuiman, Matthew; Fletcher, Astrid; Paul, Dirk S; Ford, Ian; Voortman, Trudy; Meisinger, Christa; Tjønneland, Anne; Brenner, Hermann; Palmieri, Luigi; Dallongeville, Jean-Pierre; Brunner, Eric J; Brunner, Eric J; Assmann, Gerd; Sweeting, Michael; Trevisan, Maurizio; Skeie, Guri; Gillumn, Richard F; Melander, Olle; Ford, Ian Ford; Sattar, Naveed; Lazo, Mariana; Thompson, Simon; Ferrari, Pietro; Leon, David A; Burgess, Stephen; Assmann, Gerd; Davey Smith, George; Moreno-Iribas, Conchi; Peto, Richard; Jackson, Rod; Banks, Emily; Kuller, Lewis H; Di Angelantonio, Emanuele; Danesh, John; Balkau, Beverley; Koulman, Albert; Marmot, Michael; Koenig, Wolfgang; Trevisan, Maurizio; Davidson, Karina W; Casiglia, Edoardo; Cooper, Cyrus; Arndt, Volker; Franco, Oscar H; Wennberg, Patrik; Gallacher, John; Bell, Steven; de la Cámara, Agustín Gómez; Völzke, Henry; Dahm, Christina C; Dale, Caroline E; Taylor, James O; Gillum, Richard F; Bergmann, Manuela M; Sacerdote, Carlotta; Wallace, Robert B; Quiros, J Ramon; Astle, William; Tumino, Rosario; Blazer, Dan G; Linneberg, Allan; Daimon, Makoto; Salomaa, Veikko; Sattar, Naveed; Panico, Salvatore; Howard, Barbara; Skeie, Guri; Strandberg, Timo; Stevens, David; Weiderpass, Elisabete; Nietert, Paul J; Psaty, Bruce M; Kromhout, Daan; Salamanca-Fernandez, Elena; Strandberg, Timo; Kiechl, Stefan; Astle, William; Krumholz, Harlan M; Grioni, Sara; Koulman, Albert; Palli, Domenico; Huerta, José M; Price, Jackie; Sundström, Johan; Arriola, Larraitz; Arima, Hisatomi; Weiderpass, Elisabete; Travis, Ruth C; Panagiotakos, Demosthenes B; Lazo, Mariana; Kiechl, Stefan; Karakatsani, Anna; Trichopoulou, Antonia; Kühn, Tilman; Grobbee, Diederick E; Barrett-Connor, Elizabeth; van Schoor, Natasja; Boeing, Heiner; Nietert, Paul J; Overvad, Kim; Kauhanen, Jussi; Crespo, Carlos J; Wareham, Nick; Thompson, Simon G; Langenberg, Claudia; Forouhi, Nita; Wennberg, Maria; Després, Jean-Pierre; Cushman, Mary; Cooper, Jackie A; Psaty, Bruce M; Rodriguez, Carlos J; Selmer, Randi M; Sakurai, Masaru; Shaw, Jonathan E; Knuiman, Matthew; Ferrari, Pietro; Voortman, Trudy; Meisinger, Christa; Leon, David A; Smith, George Davey; Peto, Richard; Kromhout, Daan; Verschuren, Monique; Jackson, Rod; Banks, Emily; Di Angelantonio, Emanuele; Danesh, John; Stevens, David; Wood, Angela M; Kaptoge, Stephen; Butterworth, Adam; Willeit, Peter; Warnakula, Samantha; Sato, Shinichi; Salamanca-Fernandez, Elena; Bolton, Thomas; Njølstad, Inger; Woodward, Mark; Veikko, Salomaa; Selmer, Randi M; Nordestgaard, Børge G; Yeap, Bu B; Flecther, Astrid; van der Schouw, Yvonne T; Salomaa, Veikko; Melander, Olle; Kuller, Lewis H; Balkau, Beverley; Marmot, Michael; Koenig, Wolfgang; Casiglia, Edoardo; Cooper, Cyrus; Verschuren, W M Monique; Arndt, Volker; Kaaks, Rudolf; Franco, Oscar H; Tjønneland, Anne; Wennberg, Patrik; Gallacher, John; Gómez de la Cámara, Agustín; Völzke, Henry; Dahm, Christina C; Dale, Caroline E; Bergmann, Manuela; Crespo, Carlos; Simons, Leon A; Sato, Shinichi; van der Schouw, Yvonne T; Krumholz, Harlan M; Kaaks, Rudolf; Simons, Leon A; Lagiou, Pagona; Schoufour, Josje D; Boer, Jolanda M.A; Key, Timothy J; Rodriguez, Beatriz; Lagiou, Pagona; Moreno-Iribas, Conchi; Davidson, Karina W; Njølstad, Inger; Grioni, Sara; Taylor, James O; Sacerdote, Carlotta; Wallace, Robert B; Quiros, J. Ramon; Rimm, Eric B; Tumino, Rosario; Schoufour, Josje D; Blazer III, Dan G; Linneberg, Allan; Daimon, Makoto; Panico, Salvatore; Palli, Domenico; Woodward, Mark; Howard, Barbara; Huerta, José M; Price, Jackie; Sundström, Johan; Boer, Jolanda M A; Arriola, Larraitz; Arima, Hisatomi; Travis, Ruth C; Panagiotakos, Demosthenes B; Brenner, Hermann; Nordestgaard, Børge G; Karakatsani, Anna; Trichopoulou, Antonia; Kühn, Tilman; Grobbee, Diederick E; Key, Timothy J; Barrett-Connor, Elizabeth

Description

Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599912 current drinkers without previous cardiovascular disease.Methods We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging...[Show more]

CollectionsANU Research Publications
Date published: 2018-05-31
Type: Journal article
URI: http://hdl.handle.net/1885/154651
Source: The Lancet
DOI: 10.1016/S0140-6736(18)30134-X

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