Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses
Park, Simone L; Zaid, Ali; Hor, Jyh Liang; Christo, Susan N; Prier, Julia E; Davies, Brooke; Alexandre, Yannick O; Gregory, Julia L; Russell, Tiffany A; Gebhardt, Thomas; Carbone, Francis R; Tscharke, David C; Heath, William R; Mueller, Scott N; Mackay, Laura K
Although tissue-resident memory T cells (TRM cells) are critical in fighting infection, their fate after local pathogen re-encounter is unknown. Here we found that skin TRM cells engaged virus-infected cells, proliferated in situ in response to local antigen encounter and did not migrate out of the epidermis, where they exclusively reside. As a consequence, secondary TRM cells formed from pre-existing TRM cells, as well as from precursors recruited from the circulation. Newly recruited...[Show more]
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