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Increasing antigen presentation on HSV-1-infected cells increases lesion size but does not alter neural infection or latency

Russell, Tiffany A; Velusamy, Thilaga; Tseng, Yeu-Yang; Tscharke, David C

Description

CD8+ T cells have a role in the control of acute herpes simplex virus (HSV) infection and may also be important in the maintenance of latency. In this study we have explored the consequences of boosting the efficacy of CD8+ T cells against HSV by increasing the amount of an MHC I-presented epitope on the surface of infected cells. To do this we used HSVs engineered to express an extra copy of the immunodominant CD8+ T cell epitope in C57Bl/6 mice, namely gB498 (SSIEFARL). Despite greater...[Show more]

CollectionsANU Research Publications
Date published: 2018-05
Type: Journal article
URI: http://hdl.handle.net/1885/153878
Source: The Journal of General Virology
DOI: 10.1099/jgv.0.001059
Access Rights: Open Access

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