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Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of type 1 diabetes

Arthur, JF; Shen, Y.; Chen, Y.; Qiao, J.; Ni, R.; Lu, Y.; Andrews, Robert K; Gardiner, Elizabeth; Cheng, J.

Description

Thrombosis is a life-threatening complication of diabetes. Platelet reactivity is crucial to thrombus formation, particularly in arterial vessels and in thrombotic complications causing myocardial infarction or ischaemic stroke, but diabetic patients often respond poorly to current antiplatelet medication. In this study, we used a nonhuman primate model of Type 1 diabetes to measure early downstream signalling events following engagement of the major platelet collagen receptor, glycoprotein...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/153853
Source: Journal of Diabetes Research
DOI: 10.1155/2013/370212
Access Rights: Open Access

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