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Rbf Regulates Drosophila Spermatogenesis via Control of Somatic Stem and Progenitor Cell Fate in the Larval Testis

Quinn, Leonie; Dominado, Nicole; La Marca, John E.; Siddall, Nicole A.; Heaney, James; Tran, Mai; Cai, Yu; Yu, Fengwei; Wang, Hongyan; Somers, W. Gregory; Hime, Gary R.

Description

The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or niche, to control organ growth in vivo. Here, we report the identification of two independent alleles for the highly conserved tumor suppressor gene, Retinoblastoma-family protein (Rbf), in a screen for testis phenotypes in X chromosome third-instar lethal alleles. Rbf mutant alleles exhibit overproliferation of spermatogonial cells, which is phenocopied by the...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/153834
Source: Stem Cell Reports
DOI: 10.1016/j.stemcr.2016.11.007

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