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Severe Malaria Infections Impair Germinal Center Responses by Inhibiting T Follicular Helper Cell Differentiation

Ryg-Cornejo, Victoria; Ioannidis, Lisa Julia; Ly, Ann; Chiu, Chris Yu; Tellier, Julie; Hill, Danika Lea; Preston, Simon Peter; Pellegrini, Marc; Yu, Di; Nutt, Stephen L; Kallies, Axel; Hansen, Diana


Naturally acquired immunity to malaria develops only after years of repeated exposure to Plasmodium parasites. Despite the key role antibodies play in protection, the cellular processes underlying the slow acquisition of immunity remain unknown. Using mouse models, we show that severe malaria infection inhibits the establishment of germinal centers (GCs) in the spleen. We demonstrate that infection induces high frequencies of T follicular helper (Tfh) cell precursors but results in impaired Tfh...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Cell Reports
DOI: 10.1016/j.celrep.2015.12.006
Access Rights: Open Access


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