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Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIb alpha

Carrim, N; Arthur, JF; Hamilton, J; Gardiner, Elizabeth; Andrews, Robert; Moran, N; Berndt, M; Metharom, P


Background Platelets are essential for maintaining haemostasis and play a key role in the pathogenesis of cardiovascular disease. Upon ligation of platelet receptors through subendothelial matrix proteins, intracellular reactive oxygen species (ROS) are generated, further amplifying the platelet activation response. Thrombin, a potent platelet activator, can signal through GPIbα and protease-activated receptor (PAR) 1 and PAR4 on human platelets, and recently has been implicated in the...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Redox Biology
DOI: 10.1016/j.redox.2015.10.009
Access Rights: Open Access


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