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Curcumin inhibits activation of TRPM2 channels in rat hepatocytes

Kheradpezhouh, Ehsan; Barritt, Gregory J; Rychkov, Grigori Y


Oxidative stress is a hallmark of many liver diseases including viral and drug-induced hepatitis, ischemia-reperfusion injury, and non-alcoholic steatohepatitis. One of the consequences of oxidative stress in the liver is deregulation of Ca2+ homeostasis, resulting in a sustained elevation of the free cytosolic Ca2+ concentration ([Ca2+]c) in hepatocytes, which leads to irreversible cellular damage. Recently it has been shown that liver damage induced by paracetamol and subsequent oxidative...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Redox Biology
DOI: 10.1016/j.redox.2015.11.001
Access Rights: Open Access


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