The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease
Liao, Yalin; Castello, Alfredo; Fischer, Bernd; Leicht, Stefan; Foehr, Sophia; Frese, Christian K; Ragan, Chikako; Kurscheid, Sebastian; Pagler, Eloisa; Yang, Hao; Krijgsveld, Jeroen; Hentze, Matthias; Preiss, Thomas
RNA functions through the dynamic formation of complexes with RNA-binding proteins (RBPs) in all clades of life. We determined the RBP repertoire of beating cardiomyocytic HL-1 cells by jointly employing two in vivo proteomic methods, mRNA interactome capture and RBDmap. Together, these yielded 1,148 RBPs, 391 of which are shared with all other available mammalian RBP repertoires, while 393 are thus far unique to cardiomyocytes. RBDmap further identified 568 regions of RNA contact within 368...[Show more]
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