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Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Tan, Jian; McKenzie, Craig; Vuillermin, Peter J.; Goverse, Gera; Garcia De Vinuesa, Maria Carola; Mebius, Reina E.; Macia, Laurence; Mackay, Charles R.

Description

The incidence of food allergies in western countries has increased dramatically in recent decades. Tolerance to food antigens relies on mucosal CD103+ dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells. We show that high-fiber feeding in mice improved oral tolerance and protected from food allergy. High-fiber feeding reshaped gut microbial ecology and increased the release of short-chain fatty acids (SCFAs), particularly acetate and butyrate. High-fiber feeding...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/153817
Source: Cell Reports
DOI: 10.1016/j.celrep.2016.05.047

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