Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation
Ramiscal, Roy; Parish, Ian; Lee-Young, Robert S; Babon, Jeffrey J; Blagih, Julianna; Pratama, Alvin; Martin, Jaime; Hawley, Naomi; Cappello, Jean; Canete, Pablo; Ellyard, Julia; Kershaw, Nadia J; Sweet, Rebecca; Goodnow, Christopher; Jones, Russell G; Febbraio, Mark; Garcia De Vinuesa, Maria Carola; Athanasopoulos, Vicki
T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development. ROQUIN is a post-transcriptional repressor of T cells, acting through its ROQ domain to destabilize mRNA targets important for Th1, Th17, and Tfh biology. Here, we report that ROQUIN has a paradoxical function on Tfh differentiation mediated by its RING domain: mice with a T...[Show more]
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