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Targeted pruning of a neuron's dendritic tree via femtosecond laser dendrotomy

Go, Mary-Ann; Choy, Julian; Colibaba, Alexandru; Redman, Stephen; Bachor, Hans; Stricker, Christian; Daria, Vincent

Description

Neurons are classified according to action potential firing in response to current injection. While such firing patterns are shaped by the composition and distribution of ion channels, modelling studies suggest that the geometry of dendritic branches also influences temporal firing patterns. Verifying this link is crucial to understanding how neurons transform their inputs to output but has so far been technically challenging. Here, we investigate branching-dependent firing by pruning the...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/153662
Source: Scientific Reports
DOI: 10.1038/srep19078
Access Rights: Open Access

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