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Genome-wide DNA methylation detection by MethylCap-seq and Infinium HumanMethylation450 BeadChips: An independent large-scale comparison

De Meyer, Tim; Bady, Pierre; Trooskens, Geert; Kurscheid, Sebastian; Bloch, Jocelyne; Kros, Johan M; Hainfellner, Johannes A; Stupp, Roger; Delorenzi, Mauro; Hegi, Monika E; Criekinge, Wim V

Description

Two cost-efficient genome-scale methodologies to assess DNA-methylation are MethylCap-seq and Illumina’s Infinium HumanMethylation450 BeadChips (HM450). Objective information regarding the best-suited methodology for a specific research question is scant. Therefore, we performed a large-scale evaluation on a set of 70 brain tissue samples, i.e. 65 glioblastoma and 5 non-tumoral tissues. As MethylCap-seq coverages were limited, we focused on the inherent capacity of the methodology to detect...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/153647
Source: Scientific Reports
DOI: 10.1038/srep15375
Access Rights: Open Access

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