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Asymmetric [4 + 2] annulation of 5 H -thiazol-4-ones with a chiral dipeptide-based Brønsted base catalyst

Zhu, Bo; Qiu, Shuai; Li, Jiangtao; Coote, Michelle; Lee, Zhong (Richmond); Jiang, Zhiyong


Versatile synthetic strategies that access diverse chemical substrates in a highly chemo- and stereo-selective manner are crucial but demanding. Construction of chiral molecules with multiple (hetero)-quaternary carbon stereocenters in a single fashion is a particularly significant challenge, with important applications in the synthesis of a range of bioactive compounds containing the 1,4-sulfur bridged piperidinone structural motif. The asymmetric synthesis of these entities is complicated due...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Chemical Science
DOI: 10.1039/C6SC02039A
Access Rights: Open Access


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