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Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase

Au, AE-L; Sashindranath, M; Borg, RJ; Kleifeld, Oded; Andrews, Robert; Gardiner, Elizabeth; Medcalf, RL; Samson, AL

Description

Platelet activation is a frontline response to injury, not only essential for clot formation but also important for tissue repair. Indeed, the reparative influence of platelets has long been exploited therapeutically where application of platelet concentrates expedites wound recovery. Despite this, the mechanisms of platelet-triggered cytoprotection are poorly understood. Here, we show that activated platelets accumulate in the brain to exceptionally high levels following injury and release...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/153561
Source: Cell Death & Disease
DOI: 10.1038/cddis.2014.373
Access Rights: Open Access

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