Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
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Veiga, M. Isabel; Dhingra, Satish K.; Henrich, Philipp P.; Straimer, Judith; Gnadig, Nina; Uhlemann, Anne-Catrin; Martin, Rowena; Lehane, Adele; Fidock, David A
Description
Antimalarial chemotherapy, globally reliant on artemisinin-based combination therapies (ACTs), is threatened by the spread of drug resistance in Plasmodium falciparum parasites. Here we use zinc-finger nucleases to genetically modify the multidrug resistance-1 transporter PfMDR1 at amino acids 86 and 184, and demonstrate that the widely prevalent N86Y mutation augments resistance to the ACT partner drug amodiaquine and the former first-line agent chloroquine. In contrast, N86Y increases...[Show more]
Collections | ANU Research Publications |
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Date published: | 2016 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/153555 |
Source: | Nature Communications |
DOI: | 10.1038/ncomms11553 |
Access Rights: | Open Access |
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01_Veiga_Globally_prevalent_PfMDR1_2016.pdf | 1.35 MB | Adobe PDF | ![]() |
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