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Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2

Sadrieh, Arash; Domanski, Luke; Pitt-Francis, Joe; Mann, Stefan A.; Hodkinson, Emily C.; Ng, Chai Ann; Perry, Matthew D.; Taylor, John; Gavaghan, David; Subbiah, Rajesh N.; Vandenberg, Jamie I.; Hill, Adam P


The heart rhythm disorder long QT syndrome (LQTS) can result in sudden death in the young or remain asymptomatic into adulthood. The features of the surface electrocardiogram (ECG), a measure of the electrical activity of the heart, can be equally variable in LQTS patients, posing well-described diagnostic dilemmas. Here we report a correlation between QT interval prolongation and T-wave notching in LQTS2 patients and use a novel computational framework to investigate how individual ionic...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Nature Communications
DOI: 10.1038/ncomms6069
Access Rights: Open Access


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