Skip navigation
Skip navigation

14-3-3 zeta regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, Simone M; Darbousset, Roxane; Cranmer, Susan L.; Ramshaw, Hayley S.; Orive, Stephanie L.; Sturgeon, Sharelle; Yuan, Yuping; Yao, Yu; Krycer, James R.; Woodcock, Joanne M.; Maclean, Jessica; Pitson, Stuart; Zheng, Zhaohua; Henstridge, Darren C; van der Wal, Dianne; Gardiner, Elizabeth; Berndt, Michael C.; Andrews, Robert; James, David; Lopez, Angel F.; Jackson, Shaun P

Description

The 14-3-3 family of adaptor proteins regulate diverse cellular functions including cell proliferation, metabolism, adhesion and apoptosis. Platelets express numerous 14-3-3 isoforms, including 14-3-3ζ, which has previously been implicated in regulating GPIbα function. Here we show an important role for 14-3-3ζ in regulating arterial thrombosis. Interestingly, this thrombosis defect is not related to alterations in von Willebrand factor (VWF)-GPIb adhesive function or platelet activation, but...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/153527
Source: Nature Communications
DOI: 10.1038/ncomms12862
Access Rights: Open Access

Download

File Description SizeFormat Image
01_Schoenwaelder_14-3-3_zeta_regulates_the_2016.pdf1.93 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator