Identification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis
Qian, Feng; Chung, Lisa; Zheng, Wei; Bruno, Vincent; Alexander, Roger P.; Wang, Xiaomei; Wang, Zhong; Kurscheid, Sebastian; Zhao, Hongyu; Fikrig, Erol; Gerstein, Mark; Snyder, Michael; Montgomery, Ruth R.
The West Nile virus (WNV) is an emerging infection of biodefense concern and there are no available treatments or vaccines. Here we used a high-throughput method based on a novel gene expression analysis, RNA-Seq, to give a global picture of differential gene expression by primary human macrophages of 10 healthy donors infected in vitro with WNV. From a total of 28 million reads per sample, we identified 1,514 transcripts that were differentially expressed after infection. Both predicted and...[Show more]
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