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Classification and substrate head-group specificity of membrane fatty acid desaturases

Li, Dongdi; Moorman, Ruth; Vanhercke, Thomas; Petrie, James; Singh, Surinder; Jackson, Colin


Membrane fatty acid desaturases are a diverse superfamily of enzymes that catalyze the introduction of double bonds into fatty acids. They are essential in a range of metabolic processes, such as the production of omega-3 fatty acids. However, our structure–function understanding of this superfamily is still developing and their range of activities and substrate specificities are broad, and often overlapping, which has made their systematic characterization challenging. A central issue with...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Computational and Structural Biotechnology Journal
DOI: 10.1016/j.csbj.2016.08.003
Access Rights: Open Access


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