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Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia

Bond, Jonathan; Domaschenz, Renae; Roman-Trufero, Mónica; Sabbattini, Pierangela; Ferreiros-Vidal, Isabel; Gerrard, Gareth; Asnafi, Vahid; Macintyre, Elizabeth; Merkenschlager, Matthias; Dillon, Niall

Description

Ikaros and Foxp1 are transcription factors that play key roles in normal lymphopoiesis and lymphoid malignancies. We describe a novel physical and functional interaction between the proteins, which requires the central zinc finger domain of Ikaros. The Ikaros-Foxp1 interaction is abolished by deletion of this region, which corresponds to the IK6 isoform that is commonly associated with high-risk acute lymphoblastic leukemia (ALL). We also identify the Gpr132 gene, which encodes the orphan G...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/153512
Source: Oncotarget
DOI: 10.18632/oncotarget.11688
Access Rights: Open Access

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