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Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Kang, Jian; Kusnadi, Eric P.; Ogden, Allison; Hicks, Rodney J.; Bammert, Lukas; Kutay, Ulrike; Hung, Sandy; Sanij, Elaine; Hannan, Ross; Hannan, Katherine; Pearson, Richard B


Dysregulation of RNA polymerase I (Pol I)-dependent ribosomal DNA (rDNA) transcription is a consistent feature of malignant transformation that can be targeted to treat cancer. Understanding how rDNA transcription is coupled to the availability of growth factors and nutrients will provide insight into how ribosome biogenesis is maintained in a tumour environment characterised by limiting nutrients. We demonstrate that modulation of rDNA transcription initiation, elongation and rRNA processing...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Oncotarget
DOI: 10.18632/oncotarget.10346
Access Rights: Open Access


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