Striatal Atrophy in the Behavioural Variant of Frontotemporal Dementia: Correlation with Diagnosis, Negative Symptoms and Disease Severity
Macfarlane, Matthew D; Jakabek, David; Walterfang, Mark; Vestberg, Susanna; Wilkes (previously Baglow), Fiona; Velakoulis, Dennis; Nilsson, Christer; van Westen, Danielle; Looi, Jeffrey; Santillo, Alexander
Introduction: Behavioural variant frontotemporal dementia (bvFTD) is associated with changes in dorsal striatal parts of the basal ganglia (caudate nucleus and putamen), related to dysfunction in the cortico-striato-thalamic circuits which help mediate executive and motor functions. We aimed to determine whether the size and shape of striatal structures correlated with diagnosis of bvFTD, and measures of clinical severity, behaviour and cognition. Materials and Methods: Magnetic resonance...[Show more]
|Collections||ANU Research Publications|
|Source:||PLOS ONE (Public Library of Science)|
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