Skip navigation
Skip navigation

HIV-1 Transmission during Early Antiretroviral Therapy: Evaluation of Two HIV-1 Transmission Events in the HPTN 052 Prevention Study

Ping, Li-Hua; Jabara, Cassandra B.; Rodrigo, Allen; Hudelson, Sarah E.; Piwowar-Manning, Estelle; Wang, Lei; Eshleman, Susan H.; Cohen, Myron S.; Swanstrom, Ronald

Description

In the HPTN 052 study, transmission between HIV-discordant couples was reduced by 96% when the HIV-infected partner received suppressive antiretroviral therapy (ART). We examined two transmission events where the newly infected partner was diagnosed after the HIV-infected partner (index) initiated therapy. We evaluated the sequence complexity of the viral populations and antibody reactivity in the newly infected partner to estimate the dates of transmission to the newly infected partners. In...[Show more]

dc.contributor.authorPing, Li-Hua
dc.contributor.authorJabara, Cassandra B.
dc.contributor.authorRodrigo, Allen
dc.contributor.authorHudelson, Sarah E.
dc.contributor.authorPiwowar-Manning, Estelle
dc.contributor.authorWang, Lei
dc.contributor.authorEshleman, Susan H.
dc.contributor.authorCohen, Myron S.
dc.contributor.authorSwanstrom, Ronald
dc.date.accessioned2018-11-29T22:56:15Z
dc.date.available2018-11-29T22:56:15Z
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1885/153452
dc.description.abstractIn the HPTN 052 study, transmission between HIV-discordant couples was reduced by 96% when the HIV-infected partner received suppressive antiretroviral therapy (ART). We examined two transmission events where the newly infected partner was diagnosed after the HIV-infected partner (index) initiated therapy. We evaluated the sequence complexity of the viral populations and antibody reactivity in the newly infected partner to estimate the dates of transmission to the newly infected partners. In both cases, transmission most likely occurred significantly before HIV-1 diagnosis of the newly infected partner, and either just before the initiation of therapy or before viral replication was adequately suppressed by therapy of the index. This study further strengthens the conclusion about the efficacy of blocking transmission by treating the infected partner of discordant couples. However, this study does not rule out the potential for HIV-1 transmission to occur shortly after initiation of ART, and this should be recognized when antiretroviral therapy is used for HIV-1 prevention.
dc.format.mimetypeapplication/pdf
dc.publisherPublic Library of Science
dc.sourcePLOS ONE (Public Library of Science)
dc.subjectKeywords: antiretrovirus agent; antibody response; article; case report; CD4 lymphocyte count; CD4+ T lymphocyte; disease transmission; gene amplification; genetic variability; human; Human immunodeficiency virus 1 infection; immune response; immunoreactivity; nucl
dc.titleHIV-1 Transmission during Early Antiretroviral Therapy: Evaluation of Two HIV-1 Transmission Events in the HPTN 052 Prevention Study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume8
dc.date.issued2013
local.identifier.absfor010402 - Biostatistics
local.identifier.absfor060411 - Population, Ecological and Evolutionary Genetics
local.identifier.absfor080301 - Bioinformatics Software
local.identifier.ariespublicationU3488905xPUB5616
local.type.statusPublished Version
local.contributor.affiliationPing, Li-Hua, University of North Carolina at Chapel Hill
local.contributor.affiliationJabara, Cassandra B., University of North Carolina at Chapel Hill
local.contributor.affiliationRodrigo, Allen, College of Science, ANU
local.contributor.affiliationHudelson, Sarah E., Johns Hopkins University School of Medicine
local.contributor.affiliationPiwowar-Manning, Estelle, Johns Hopkins University School of Medicine
local.contributor.affiliationWang, Lei, Fred Hutchinson Cancer Research Center
local.contributor.affiliationEshleman, Susan H., Johns Hopkins University School of Medicine
local.contributor.affiliationCohen, Myron S., University of North Carolina at Chapel Hill
local.contributor.affiliationSwanstrom, Ronald, University of North Carolina at Chapel Hill
local.bibliographicCitation.issue9
local.bibliographicCitation.startpagee71557
local.bibliographicCitation.lastpagee71557
local.identifier.doi10.1371/journal.pone.0071557
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
dc.date.updated2018-11-29T08:10:54Z
local.identifier.scopusID2-s2.0-84884541971
local.identifier.thomsonID000325025200004
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Ping_HIV-1_Transmission_during_2013.pdf371.97 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator