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Methods to determine the lagrangian shear experienced by platelets during thrombus growth

Pinar, I; Arthur, JF; Andrews, Robert; Gardiner, Elizabeth; Ryan, K; Carberry, J

Description

Platelets can become activated in response to changes in flow-induced shear; however, the underlying molecular mechanisms are not clearly understood. Here we present new techniques for experimentally measuring the flow-induced shear rate experienced by platelets prior to adhering to a thrombus. We examined the dynamics of blood flow around experimentally grown thrombus geometries using a novel combination of experimental (ex vivo) and numerical (in silico) methodologies. Using a microcapillary...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/153437
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0144860
Access Rights: Open Access

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