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Refined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death

Vatin, M; Burgio, Gaetan; Renault, G; Laissue, P; Firlej, V; Mondon, F; Montagutelli, Xavier; Vaiman, D; Serres, C; Ziyyat, A


Recurrent spontaneous abortion (RSA) is defined as the loss of three or more consecutive pregnancies during the first trimester of embryonic intrauterine development. This kind of human infertility is frequent among the general population since it affects 1 to 5% of women. In half of the cases the etiology remains unelucidated. In the present study, we used interspecific recombinant congenic mouse strains (IRCS) in the aim to identify genes responsible for embryonic lethality. Applying a...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0043356
Access Rights: Open Access


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