Acute Simvastatin Inhibits K-ATP Channels of Porcine Coronary Artery Myocytes
Seto, Sai Wang; Au, Alice Lai Shan; Poon, Christina Chui Wa; Yeung, John Hok Keung; Li, Rachel; Kong, Siu Kai; Ngai, Sai Ming; Wan, Song; Ho, Ho Pui; Lee, Simon Ming Yuen; Hoi, Maggie Pui Man; Chan, Shun-Wan; Kwan, Y. W.
Background Statins (3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors) consumption provides beneficial effects on cardiovascular systems. However, effects of statins on vascular KATP channel gatings are unknown. Methods Pig left anterior descending coronary artery and human left internal mammary artery were isolated and endothelium-denuded for tension measurements and Western immunoblots. Enzymatically-dissociated/cultured arterial myocytes were used for patch-clamp...[Show more]
|Collections||ANU Research Publications|
|Source:||PLOS ONE (Public Library of Science)|
|Access Rights:||Open Access|
|01_Seto_Acute_Simvastatin_Inhibits_2013.pdf||3.3 MB||Adobe PDF|
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