Skip navigation
Skip navigation

Acute Simvastatin Inhibits K-ATP Channels of Porcine Coronary Artery Myocytes

Seto, Sai Wang; Au, Alice Lai Shan; Poon, Christina Chui Wa; Yeung, John Hok Keung; Li, Rachel; Kong, Siu Kai; Ngai, Sai Ming; Wan, Song; Ho, Ho Pui; Lee, Simon Ming Yuen; Hoi, Maggie Pui Man; Chan, Shun-Wan; Kwan, Y. W.


Background Statins (3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitors) consumption provides beneficial effects on cardiovascular systems. However, effects of statins on vascular KATP channel gatings are unknown. Methods Pig left anterior descending coronary artery and human left internal mammary artery were isolated and endothelium-denuded for tension measurements and Western immunoblots. Enzymatically-dissociated/cultured arterial myocytes were used for patch-clamp...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0066404
Access Rights: Open Access


File Description SizeFormat Image
01_Seto_Acute_Simvastatin_Inhibits_2013.pdf3.3 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator