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Differential Ligand Binding Affinities of Human Estrogen Receptor-alpha Isoforms

Lin, Amanda H. Y.; Li, Rachel; Ho, Eva Y. W.; Leung, George P. H.; Leung, Susan W. S.; Vanhoutte, Paul M.; Man, Ricky Y. K.


Rapid non-genomic effects of 17β-estradiol are elicited by the activation of different estrogen receptor-α isoforms. Presence of surface binding sites for estrogen have been identified in cells transfected with full-length estrogen receptor-α66 (ER66) and the truncated isoforms, estrogen receptor-α46 (ER46) and estrogen receptor-α36 (ER36). However, the binding affinities of the membrane estrogen receptors (mERs) remain unknown due to the difficulty of developing of stable mER-transfected cell...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0063199
Access Rights: Open Access


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