Skip navigation
Skip navigation

Relaxation effect of abacavir on rat basilar arteries

Li, Rachel; Yang, C; Chan, S. W.; Hoi , Maggie PM; Lee , Simon MY; Leung, George P. H.

Description

Background The use of abacavir has been linked with increased cardiovascular risk in patients with human immunodeficiency virus infection; however, the mechanism involved remains unclear. We hypothesize that abacavir may impair endothelial function. In addition, based on the structural similarity between abacavir and adenosine, we propose that abacavir may affect vascular contractility through endogenous adenosine release or adenosine receptors in blood vessels. Methods The relaxation...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/153421
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0123043
Access Rights: Open Access

Download

File Description SizeFormat Image
01_Li_Relaxation_effect_of_abacavir_2015.pdf883.1 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator