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Relaxation effect of abacavir on rat basilar arteries

Li, Rachel; Yang, C; Chan, S. W.; Hoi , Maggie PM; Lee , Simon MY; Leung, George P. H.


Background The use of abacavir has been linked with increased cardiovascular risk in patients with human immunodeficiency virus infection; however, the mechanism involved remains unclear. We hypothesize that abacavir may impair endothelial function. In addition, based on the structural similarity between abacavir and adenosine, we propose that abacavir may affect vascular contractility through endogenous adenosine release or adenosine receptors in blood vessels. Methods The relaxation...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0123043
Access Rights: Open Access


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