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gamma-Hydroxybutyric Acid (GHB) Is Not an Agonist of Extrasynaptic GABA(A) Receptors

Connelly, William; Errington, Adam; Crunelli, Vincenzo

Description

γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABAB receptors with millimolar affinity, but also binds with much higher affinity to another site, known as the GHB receptor. While a body of evidence has shown that GHB does not bind to GABAA receptors widely, recent evidence has suggested that the GHB receptor is in fact on extrasynaptic α4β1δ GABAA receptors, where GHB acts as an agonist with...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/153420
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0079062
Access Rights: Open Access

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