gamma-Hydroxybutyric Acid (GHB) Is Not an Agonist of Extrasynaptic GABA(A) Receptors
γ-Hydroxybutyric acid (GHB) is an endogenous compound and a drug used clinically to treat the symptoms of narcolepsy. GHB is known to be an agonist of GABAB receptors with millimolar affinity, but also binds with much higher affinity to another site, known as the GHB receptor. While a body of evidence has shown that GHB does not bind to GABAA receptors widely, recent evidence has suggested that the GHB receptor is in fact on extrasynaptic α4β1δ GABAA receptors, where GHB acts as an agonist with...[Show more]
|Collections||ANU Research Publications|
|Source:||PLOS ONE (Public Library of Science)|
|Access Rights:||Open Access|
|01_Connelly_gamma-Hydroxybutyric_Acid_2013.pdf||1.42 MB||Adobe PDF|
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