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Polymorphisms in the receptor tyrosine kinase MERTK gene are associated with Multiple Sclerosis susceptibility

Ma, GZM; Stankovich, J; Kilpatrick, TJ; Binder, Michele D.; Field, Judith; Bahlo, Melanie; Booth, David; Broadley, Simon; Brown, M.A.; Browning , BL; Browning, SR; Butzkueven, H; Carroll, WM; Danoy, P; Foote, Simon; Griffiths, Lyn; Heard, RN; Kermode, AG; Lechner-Scott, Jeanette; Moscato, Pablo Alberto; Perreau, Victoria M; Scott, Rodney; Slee, Mark; Stewart, Graeme; Taylor, B V; Wiley, J

Description

Multiple sclerosis (MS) is a debilitating, chronic demyelinating disease of the central nervous system affecting over 2 million people worldwide. The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) have been implicated as important players during demyelination in both animal models of MS and in the human disease. We therefore conducted an association study to identify single nucleotide polymorphisms (SNPs) within genes encoding the TAM receptors and their ligands associated with...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/153410
Source: PLOS ONE (Public Library of Science)
DOI: 10.1371/journal.pone.0016964
Access Rights: Open Access

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