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Healthcare resource utilisation associated with herpes zoster in a prospective cohort of older Australian adults

Karki, Surendra; Newall, Anthony T; MacIntyre, C Raina; Heywood, A E; McIntyre, Peter B; Banks, Emily; Liu, Bette

Description

Background Herpes zoster (HZ) is a common condition that increases in incidence with older age but vaccines are available to prevent the disease. However, there are limited data estimating the health system burden attributable to herpes zoster by age. Methods In this study, we quantified excess healthcare resource usage associated with HZ during the acute/sub-acute period of disease (21days before to 90 days after onset) in 5952 cases and an equal number of controls matched on age,...[Show more]

dc.contributor.authorKarki, Surendra
dc.contributor.authorNewall, Anthony T
dc.contributor.authorMacIntyre, C Raina
dc.contributor.authorHeywood, A E
dc.contributor.authorMcIntyre, Peter B
dc.contributor.authorBanks, Emily
dc.contributor.authorLiu, Bette
dc.date.accessioned2018-11-29T22:56:05Z
dc.date.available2018-11-29T22:56:05Z
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1885/153396
dc.description.abstractBackground Herpes zoster (HZ) is a common condition that increases in incidence with older age but vaccines are available to prevent the disease. However, there are limited data estimating the health system burden attributable to herpes zoster by age. Methods In this study, we quantified excess healthcare resource usage associated with HZ during the acute/sub-acute period of disease (21days before to 90 days after onset) in 5952 cases and an equal number of controls matched on age, sex, and prior healthcare resource usage. Estimates were adjusted for potential confounders in multivariable regression models. Using population-based estimates of HZ incidence, we calculated the age-specific excess number of health service usage events attributable to HZ in the population. Results Per HZ case, there was an average of 0.06 (95% CI 0.04–0.08) excess hospitalisations, 1.61 (95% CI 1.51–1.69) excess general practitioner visits, 1.96 (95% CI 1.86–2.15) excess prescriptions filled and 0.11 (95% CI 0.09–0.13) excess emergency department visits. The average number of healthcare resource use events, and the estimated excess per 100,000 population increased with increasing age but were similar for men and women, except for higher rates of hospitalisation in men. The excess annual HZ associated burden of hospitalisations was highest in adults ≥80 years (N = 2244, 95%CI 1719–2767); GP visits was highest in those 60–69 years (N = 50567, 95%CI 39958–61105), prescriptions and ED visits were highest in 70–79 years (N = 50524, 95%CI 40634–60471 and N = 2891, 95%CI 2319–3449 respectively). Conclusions This study provides important data to establish the healthcare utilisation associated with HZ against which detailed cost-effectiveness analyses of HZ immunisation in older adults can be conducted.
dc.format.mimetypeapplication/pdf
dc.publisherPublic Library of Science
dc.sourcePLOS ONE (Public Library of Science)
dc.titleHealthcare resource utilisation associated with herpes zoster in a prospective cohort of older Australian adults
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume11
dc.date.issued2016
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.absfor111700 - PUBLIC HEALTH AND HEALTH SERVICES
local.identifier.ariespublicationa383154xPUB4208
local.type.statusPublished Version
local.contributor.affiliationKarki, Surendra, University of New South Wales
local.contributor.affiliationNewall, Anthony T, University of New South Wales
local.contributor.affiliationMacIntyre, C Raina, University of New South Wales
local.contributor.affiliationHeywood, A E, University New South Wales
local.contributor.affiliationMcIntyre, Peter B, Children's Hospital at Westmead and University of Sydney
local.contributor.affiliationBanks, Emily, College of Health and Medicine, ANU
local.contributor.affiliationLiu, Bette, University of New South Wales
local.bibliographicCitation.issue8
local.bibliographicCitation.startpagee0160446
local.bibliographicCitation.lastpagee0160446
local.identifier.doi10.1371/journal.pone.0160446
dc.date.updated2018-11-29T08:09:58Z
local.identifier.scopusID2-s2.0-84982145759
local.identifier.thomsonID000381110700046
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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