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A cross-metathesis approach to novel pantothenamide derivatives

Guan, Jinming; Hachey, Matthew; Puri, Lekha; Howieson, Vanessa; Saliba, Kevin; Auclair, Karine


Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substituents. Here we report a new synthetic route that exploits the known allyl derivative, allowing for the installation of larger groups via crossmetathesis. The method was applied in the synthesis of a new pantothenamide with improved stability in...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Beilstein Journal of Organic Chemistry
DOI: 10.3762/bjoc.12.95
Access Rights: Open Access


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