A cross-metathesis approach to novel pantothenamide derivatives
Pantothenamides are known for their in vitro antimicrobial activity. Our group has previously reported a new stereoselective route to access derivatives modified at the geminal dimethyl moiety. This route however fails in the addition of large substituents. Here we report a new synthetic route that exploits the known allyl derivative, allowing for the installation of larger groups via crossmetathesis. The method was applied in the synthesis of a new pantothenamide with improved stability in...[Show more]
|Collections||ANU Research Publications|
|Source:||Beilstein Journal of Organic Chemistry|
|Access Rights:||Open Access|
|01_Guan_A_cross-metathesis_approach_to_2016.pdf||336.98 kB||Adobe PDF|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.