HIF1 alpha deficiency reduces inflammation in a mouse model of proximal colon cancer
Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative regulators of HIF1α. Aberrant overexpression of HIF1α in many different cancers has led to intensive efforts to develop HIF1α-targeted therapies. However, the role of HIF1α is still poorly understood...[Show more]
|Collections||ANU Research Publications|
|Source:||Disease Models and Mechanisms|
|Access Rights:||Open Access|
|01_Mladenova_HIF1_alpha_deficiency_reduces_2015.pdf||1.79 MB||Adobe PDF|
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