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HIF1 alpha deficiency reduces inflammation in a mouse model of proximal colon cancer

Mladenova, Dessislava; Dahlstrom, Jane; Tran, Phuong N.; Benthani, Fahad; Ng, Irvin; Pangon, Laurent; Currey, Nicola; Kohonen-Corish, Maija R J; Bean, Elaine


Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative regulators of HIF1α. Aberrant overexpression of HIF1α in many different cancers has led to intensive efforts to develop HIF1α-targeted therapies. However, the role of HIF1α is still poorly understood...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Disease Models and Mechanisms
DOI: 10.1242/dmm.019000
Access Rights: Open Access


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