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A physarum-inspired prize-collecting steiner tree approach to identify subnetworks for drug repositioning

Halgamuge, Saman; Verspoor, Karin; Sun, Yahui; Hameed, Pathima Nusrath

Description

Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition drugs as pharmacological data is large and complex. Subnetwork identification has already been used to simplify the visualization and interpretation of biological data, but it has not been applied to drug repositioning so far. In this paper, we fill this gap by proposing a new Physarum-inspired Prize-Collecting Steiner Tree algorithm...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
URI: http://hdl.handle.net/1885/153324
Source: BMC Systems Biology
DOI: 10.1186/s12918-016-0371-3
Access Rights: Open Access

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