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The Effects of Leptin Replacement on Neural Plasticity

Da Paz Filho, Gilberto


Leptin, an adipokine synthesized and secreted mainly by the adipose tissue, has multiple effects on the regulation of food intake, energy expenditure, and metabolism. Its recently-approved analogue, metreleptin, has been evaluated in clinical trials for the treatment of patients with leptin deficiency due to mutations in the leptin gene, lipodystrophy syndromes, and hypothalamic amenorrhea. In such patients, leptin replacement therapy has led to changes in brain structure and function in intra-...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Neural Plasticity
DOI: 10.1155/2016/8528934
Access Rights: Open Access


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