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Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells

Li, Rachel; Yang, Cui; Kwan, Y. W.; Chan, S. W.; Lee, Simon Ming Yuen; Leung, George P. H.


The serotonin (5-HT) uptake system is supposed to play a crucial part in vascular functions by "fine-tuning" the local concentration of 5-HT in the vicinity of 5-HT2 receptors in vascular smooth muscle cells. In this study, the mechanism of 5-HT uptake in human brain vascular smooth muscle cells (HBVSMCs) was investigated. [3H]5-HT uptake in HBVSMCs was Na+-independent. Kinetic analyses of [3H]5-HT uptake in HBVSMCs revealed a Km of 50.36 ± 10.2 mM and a Vmax of 1033.61 ± 98.86 pmol/mg...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Frontiers in Pharmacology
DOI: 10.3389/fphar.2013.00014
Access Rights: Open Access


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