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Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups

Ferrari, Diana C; Mdzomba, Baya J; Dehorter, Nathalie; Lopez, Catherine; Michel, Francois J; Libersat, Frederic; Hammond, Constance


Midbrain dopaminergic neurons (mDA neurons) are essential for the control of diverse motor and cognitive behaviors. However, our understanding of the activity of immature mDA neurons is rudimentary. Rodent mDA neurons migrate and differentiate early in embryonic life and dopaminergic axons enter the striatum and contact striatal neurons a few days before birth, but when these are functional is not known. Here, we recorded Ca 2+ transients and Na + spikes from embryonic (E16-E18) and early...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Frontiers in Cellular Neuroscience
DOI: 10.3389/fncel.2012.00007
Access Rights: Open Access


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