mRNA Structural Constraints on EBNA1 Synthesis Impact on In Vivo Antigen Presentation and Early Priming of CD8(+) T Cells
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Tellam, Judy; Zhong, Jie; Lekieffre, Lea; Bhat, Purnima; Martinez, M; Croft, Nathan P; Kaplan, Warren; Tellam, R; Khanna, Rajiv
Description
Recent studies have shown that virally encoded mRNA sequences of genome maintenance proteins from herpesviruses contain clusters of unusual structural elements, G-quadruplexes, which modulate viral protein synthesis. Destabilization of these G-quadruplexes can override the inhibitory effect on self-synthesis of these proteins. Here we show that the purine-rich repetitive mRNA sequence of Epstein-Barr virus encoded nuclear antigen 1 (EBNA1) comprising G-quadruplex structures, limits both the...[Show more]
Collections | ANU Research Publications |
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Date published: | 2014 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/153184 |
Source: | PLoS Pathogens |
DOI: | 10.1371/journal.ppat.1004423 |
Access Rights: | Open Access |
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File | Description | Size | Format | Image |
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01_Tellam_mRNA_Structural_Constraints_on_2014.pdf | 3.36 MB | Adobe PDF |
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