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mRNA Structural Constraints on EBNA1 Synthesis Impact on In Vivo Antigen Presentation and Early Priming of CD8(+) T Cells

Tellam, Judy; Zhong, Jie; Lekieffre, Lea; Bhat, Purnima; Martinez, M; Croft, Nathan P; Kaplan, Warren; Tellam, R; Khanna, Rajiv


Recent studies have shown that virally encoded mRNA sequences of genome maintenance proteins from herpesviruses contain clusters of unusual structural elements, G-quadruplexes, which modulate viral protein synthesis. Destabilization of these G-quadruplexes can override the inhibitory effect on self-synthesis of these proteins. Here we show that the purine-rich repetitive mRNA sequence of Epstein-Barr virus encoded nuclear antigen 1 (EBNA1) comprising G-quadruplex structures, limits both the...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1004423
Access Rights: Open Access


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