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Study of cell differentiation by phylogenetic analysis using histone modification data

Nair, Nishanth Ulhas; Lin, Yu; Manasovska, Ana; Antic, Jelena; Grnarova, Paulina; Das Sahu, Avinash; Bucher, Philipp; Moret, Bernard


Background: In cell differentiation, a cell of a less specialized type becomes one of a more specialized type, even though all cells have the same genome. Transcription factors and epigenetic marks like histone modifications can play a significant role in the differentiation process.Results: In this paper, we present a simple analysis of cell types and differentiation paths using phylogenetic inference based on ChIP-Seq histone modification data. We precisely defined the notion of cell-type...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: BMC Bioinformatics
DOI: 10.1186/1471-2105-15-269
Access Rights: Open Access


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