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Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Huang, Wen; Massouras, Andreas; Inoue, Yutaka; Peiffer, Jason; Ramia, Miquel; Tarone, Aaron M; Turlapati, Lavanya; Zichner, Thomas; Zhu, Dianhui; Lyman, Richard F; Stone, Eric


The Drosophila melanogaster Genetic Reference Panel (DGRP) is a community resource of 205 sequenced inbred lines, derived to improve our understanding of the effects of naturally occurring genetic variation on molecular and organismal phenotypes. We used an integrated genotyping strategy to identify 4,853,802 single nucleotide polymorphisms (SNPs) and 1,296,080 non-SNP variants. Our molecular population genomic analyses show higher deletion than insertion mutation rates and stronger purifying...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Genome Research
DOI: 10.1101/gr.171546.113
Access Rights: Open Access


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