C-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol i availability during granulocyte differentiation
Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate a robust reduction of Pol I loading onto rDNA that along with a depletion of the MYC target gene upstream binding factor (UBF) and a switch from epigenetically active to silent rDNA accompanies this MYC reduction. We hypothesized that MYC may coordinate these mechanisms via direct regulation of multiple components of...[Show more]
|Collections||ANU Research Publications|
|Source:||Nucleic Acids Research|
|01_Poortinga_C-MYC_coordinately_regulates_2011.pdf||1.09 MB||Adobe PDF|
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