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C-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol i availability during granulocyte differentiation

Poortinga, Gretchen; Wall, Meaghan; Sanij, Elaine; Siwicki, Kasia; Ellul, Jason; Brown, Daniel; Holloway, Timothy P.; Hannan, Ross; McArthur, Grant


Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate a robust reduction of Pol I loading onto rDNA that along with a depletion of the MYC target gene upstream binding factor (UBF) and a switch from epigenetically active to silent rDNA accompanies this MYC reduction. We hypothesized that MYC may coordinate these mechanisms via direct regulation of multiple components of...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Nucleic Acids Research
DOI: 10.1093/nar/gkq1205


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