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Inducible Presynaptic Glutamine Transport Supports Glutamatergic Transmission at the Calyx of Held Synapse

Billups, Daniela; Marx, Mari-Carmen; Mela, Ioanna; Billups, Brian


he mechanisms by which the excitatory neurotransmitter glutamate is recycled at synapses are currently unknown. By examining the functional expression of plasma membrane transporters at presynaptic terminals, we aim to elucidate some of the mechanisms of glutamate recycling. Using whole-cell voltage-clamp recordings from rat calyx of Held presynaptic terminals, our data show, for the first time, that the glutamate precursor glutamine causes the direct activation of an electrogenic,...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.1466-13.2013
Access Rights: Open Access


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