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Calcium-Dependent But Action Potential-Independent BCM-Like Metaplasticity in the Hippocampus

Hulme, Sarah; Jones, Owen; Ireland, David R; Abraham, Wickliffe C


The Bienenstock, Cooper and Munro (BCM) computational model, which incorporates a metaplastic sliding threshold for LTP induction, accounts well for experience-dependent changes in synaptic plasticity in the visual cortex. BCM-like metaplasticity over a shorter timescale has also been observed in the hippocampus, thus providing a tractable experimental preparation for testing specific predictions of the model. Here, using extracellular and intracellular electrophysiological recordings from...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.0634-12.2012
Access Rights: Open Access


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