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The Redox Cofactor F-420 Protects Mycobacteria from Diverse Antimicrobial Compounds and Mediates a Reductive Detoxification System

Thanavit, Jirapanjawat; Ney, Blair; Taylor, Matthew c.; Warden, Andrew C; Shahana, Afroze; Russell, Robyn J; Lee, Brendon; Jackson, Colin; Oakeshott , John; Pandey, Gunjan; Greening, Chris


A defining feature of mycobacterial redox metabolism is the use of an unusual deazaflavin cofactor, F420. This cofactor enhances the persistence of environmental and pathogenic mycobacteria, including after antimicrobial treatment, although the molecular basis for this remains to be understood. In this work, we explored our hypothesis that F420 enhances persistence by serving as a cofactor in antimicrobial-detoxifying enzymes. To test this, we performed a series of phenotypic, biochemical, and...[Show more]

CollectionsANU Research Publications
Date published: 2016
Type: Journal article
Source: Applied and Environmental Microbiology
DOI: 10.1128/AEM.02500-16
Access Rights: Open Access


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