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Lessons from toxicology: Developing a 21st-century paradigm for medical research

Langley, Gill R.; Austin, Christopher P.; Balapure, Anil K.; Birnbaum, Linda S.; Bucher, John R.; Fentem, Julia; Fitzpatrick, Suzanne C.; Fowle III, John R.; Kavlovk, Robert J.; Kitano, Hiroaki; Lidbury, Brett; Muotri, Alysson R.; Peng, Shuang-Qing; Sakharov, Dmitry; Seidle, Troy; Trez, Thales; Tonevitsky, Alexander; van de Stolpe, Anja; Whelan, Maurice; Willett, Catherine


Biomedical developments in the 21st century provide an unprecedented opportunity to gain a dynamic systems-level and human-specific understanding of the causes and pathophysiologies of disease. This understanding is a vital need, in view of continuing failures in health research, drug discovery, and clinical translation. The full potential of advanced approaches may not be achieved within a 20th-century conceptual framework dominated by animal models. Novel technologies are being integrated...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Environmental Health Perspectives
DOI: 10.1289/ehp.1510345
Access Rights: Open Access


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