Direct observation of structurally encoded metal discrimination and ether bond formation in a heterodinuclear metalloprotein
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Griese, Julia; Roos, Katarina; Cox, Nicholas; Shafaat, Hannah S.; Branca, Rui M M; Lehtiö, Janne; Graslund, Astrid; Lubitz, Wolfgang; Siegbahn, Per E.M.; Hogbom, Martin
Description
Although metallocofactors are ubiquitous in enzyme catalysis, how metal binding specificity arises remains poorly understood, especially in the case of metals with similar primary ligand preferences such as manganese and iron. The biochemical selection of manganese over iron presents a particularly intricate problem because manganese is generally present in cells at a lower concentration than iron, while also having a lower predicted complex stability according to the Irving–Williams series...[Show more]
Collections | ANU Research Publications |
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Date published: | 2013 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/152384 |
Source: | PNAS - Proceedings of the National Academy of Sciences of the United States of America |
DOI: | 10.1073/pnas.1304368110 |
Access Rights: | Open Access |
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01_Griese_Direct_observation_of_2013.pdf | 822.32 kB | Adobe PDF |
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