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Transient compartmentalization of simian immunodeficiency virus variants in the breast milk of african green monkeys

Ho, Carrie; Wu, Steven; Amos, Joshua D.; Colvin, Lisa; Smith, Shannon D.; Wilks, Andrew B.; DeMarco, C. Todd; Brinkley, Christie; Denny, Thomas N.; Schmitz, Joern E.; Rodrigo, Allen; Permar, Sallie R.

Description

Natural hosts of simian immunodeficiency virus (SIV), African green monkeys (AGMs), rarely transmit SIV via breast-feeding. In order to examine the genetic diversity of breast milk SIV variants in this limited-transmission setting, we performed phylogenetic analysis on envelope sequences of milk and plasma SIV variants of AGMs. Low-diversity milk virus populations were compartmentalized from that in plasma. However, this compartmentalization was transient, as the milk virus lineages did not...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/152344
Source: Journal of Virology
DOI: 10.1128/JVI.01643-13
Access Rights: Open Access

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